Biomaterial Research Center

Polymers

Synthesis
Elastomers
Fiber formers
Adhesives
Biodegradable
Biotextiles
Biopolymers
Pyrolytic carbon
Intelligent gels
Hydrogels

Metals

Ni-Ti alloys
Stainless steel
Gold alloys
Co- Cr alloys

Ceramics / glasses

Alumina (single & poly crystalline)
Porous / nonporous
Bioactive glass
Hydroxy apatite
Calcium sulfate
Calcium phosphate

Composites

Particle reinforced
Fiber (continuous - discontinuous)
Reinforced
Monolithic/ laminates

Surface Treatments / Modifications

Physical:

Plasma etching
Plasma deposition
Ion plating
Physisorption

Chemical:

Chemical reactions
Oxidation
Chemical etching
Fluorination
Silinization
Heparinization

Characterization / properties

· Chemical

· Physical

· Mechanical

· Biological

· Corrosion

B. BIOMATERIALS PROCESSING and Engineering

· Polymeric biomaterials (casting, spinning, molding, membranes, conduits, textured &

· Porous)

· Metallic biomaterials (stents, wires, porous, plates, joints, screws …)

· Ceramic biomaterials (joints, porous, screw)

· Composites (particle reinforced), fiber (glass, carbon, ceramics- continuous

discontinuous; single/ multilayer; uni- / multi – direction)

C. HOST REACTION TO BIOMATERIALS & EVALUATION

· Biocompatibility

Blood compatibility

· Protein adsorption

· Platelet formation

· Tumor genesis

· Biofilms

· Wear / biodegradation

· Corrosion

· Toxicity consequent to wear/corrosion/biodegradation

· Biological effects (adsorption, enzyme degradation, calcification)

· Systemic interaction

· Fatigue

D. BIOMATERIALS APPLICATIONS

Medical

Skeletal System

· Joint replacements (hip, knee)

· Bone plates for fracture fixation

· Bone cement

· Bony defect

· Orthopedic implants

· Artificial tendon &

· ligament

· Maxillofacial implants

Cardiovascular System

· Blood vessel prosthesis

· Artificial blood

· Heart valves

· Vascular grafts

· Catheters

· Coronary stents

Implants for retinal surgery

· Contact lenses

· Corneal bandge

· Vitreous implants

Senses

· Cochlear replacements

· Intraocular lenses

· Implants for retinal surgery

· Contact lenses

· Corneal bandge

· Vitreous implants

· Vicoelastic solution

· Eye shields

· Acrylate adhesives

· Drainage tubes

Others

· Urological devices

· Catheters

· Surgical sutures

· Bulk space fillers

Diagnostic

· Immunolatices

· ELISA substrate

· Magnetic particles

· Fluorescent particles

· Molecular imprints

· Biosensors

Dental

Cements

· Porcelains

· Impression materials

· Gypsum compounds

waxes

· Prosthetics materials

· Anterior esthetic materials

· Filling & restorative

Metals

· Amalgams

· Gold alloys

· Co- Cr alloy

· Amalgams

· Nitinol

· Base metal alloys

· Ti- Al alloy

· Oral implants

Polymers

· Elastomers

· Base liner

· Varnishes

· Adhesives

· Sealants

· Acrylics

Pharmaceutical

Drug and Gene delivery systems

· Diffusive

· Osmotic

· Chemical

· Inteligent:

· Thermal

· Chemical

· Magnetic

· Physical

Particulates

· Micro

· Nano

· Micelles

· Liposomes

· Dendrimers

Genetic Engineering

· Gene porters

· Liposomes

· Dendrimers

· Polymersomes

· Cationic lipids

· Cationic polymer

· Dendrosomes

· Inorganics:

· Ca- phosphate

· Al- Phophate

Veterinary

· Vaccine Adjuvants

· Oils

· Emulsifiers

· Inorganics:

· Al- Phosphate

· Ca- Phosphate

· ISCOMS

· Liposomes

· Particulate polymer

E. PRECLINICAL TRAIL

· Tissue engineering

· Animal model studies